Vladimir Tolmachev Selected Research

Therapeutics

4/2024	Comparison of approaches for increasing affinity of affibody molecules for imaging of B7-H3: dimerization and affinity maturation.
4/2024	Comparative Preclinical Evaluation of HYNIC-Modified Designed Ankyrin Repeat Proteins G3 for the 99mTc-Based Imaging of HER2-Expressing Malignant Tumors.
2/2023	Feasibility of Co-Targeting HER3 and EpCAM Using Seribantumab and DARPin-Toxin Fusion in a Pancreatic Cancer Xenograft Model.
1/2023	Preclinical Characterisation of PSMA/GRPR-Targeting Heterodimer [68Ga]Ga-BQ7812 for PET Diagnostic Imaging of Prostate Cancer: A Step towards Clinical Translation.
1/2023	Human Epidermal Growth Factor Receptor 2-Targeting [68Ga]Ga-ABY-025 PET/CT Predicts Early Metabolic Response in Metastatic Breast Cancer.
11/2022	Comparative Preclinical Evaluation of Peptide-Based Chelators for the Labeling of DARPin G3 with 99mTc for Radionuclide Imaging of HER2 Expression in Cancer.
8/2022	Evaluation of an Affibody-Based Binder for Imaging of Immune Check-Point Molecule B7-H3.
8/2022	Experimental HER2-Targeted Therapy Using ADAPT6-ABD-mcDM1 in Mice Bearing SKOV3 Ovarian Cancer Xenografts: Efficacy and Selection of Companion Imaging Counterpart.
5/2022	Experimental Therapy of HER2-Expressing Xenografts Using the Second-Generation HER2-Targeting Affibody Molecule 188Re-ZHER2:41071.
5/2022	Epithelial cell adhesion molecule‑targeting designed ankyrin repeat protein‑toxin fusion Ec1‑LoPE exhibits potent cytotoxic action in prostate cancer cells.

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Vladimir Tolmachev Research Topics

Disease

190	Neoplasms (Cancer) 05/2024 - 01/2002
34	Prostatic Neoplasms (Prostate Cancer) 05/2024 - 04/2011
30	Breast Neoplasms (Breast Cancer) 03/2024 - 08/2004
18	Neoplasm Metastasis (Metastasis) 05/2023 - 11/2004
14	Carcinoma (Carcinomatosis) 05/2020 - 11/2004
8	Ovarian Neoplasms (Ovarian Cancer) 11/2022 - 06/2005
6	Squamous Cell Carcinoma of Head and Neck 12/2019 - 11/2004
5	Glioma (Gliomas) 01/2018 - 05/2003
5	Glioblastoma (Glioblastoma Multiforme) 01/2018 - 08/2003
5	Colorectal Neoplasms (Colorectal Cancer) 01/2014 - 10/2005
5	Neoplasm Micrometastasis 09/2009 - 02/2002
4	Renal Cell Carcinoma (Grawitz Tumor) 01/2023 - 02/2015
3	Lymphoma (Lymphomas) 01/2023 - 05/2020
2	Pancreatic Neoplasms (Pancreatic Cancer) 02/2023 - 06/2020
2	Disease Progression 01/2021 - 06/2019
2	Adenocarcinoma 02/2020 - 05/2012
2	Squamous Cell Carcinoma (Epidermoid Carcinoma) 02/2016 - 01/2011
1	Stomach Neoplasms (Stomach Cancer) 08/2022
1	Osteosarcoma (Osteogenic Sarcoma) 05/2022

Drug/Important Bio-Agent (IBA)

74	Radioisotopes (Radionuclides)IBA 05/2024 - 02/2002
38	ErbB Receptors (EGF Receptor)IBA 01/2023 - 08/2004
31	Proteins (Proteins, Gene)FDA Link 03/2024 - 02/2004
26	1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidIBA 01/2023 - 02/2007
22	Bombesin Receptors (Bombesin Receptor)IBA 04/2024 - 01/2013
20	Chelating AgentsIBA 04/2024 - 11/2006
19	Trastuzumab (Herceptin)FDA Link 04/2023 - 06/2005
19	Monoclonal AntibodiesIBA 08/2022 - 11/2004
16	AntigensIBA 05/2024 - 10/2005
15	human ERBB2 proteinIBA 01/2023 - 06/2005
14	1,4,7- triazacyclononane- N,N',N''- triacetic acid (NOTA)IBA 04/2024 - 05/2011
12	1- (1,3- carboxypropyl)- 4,7- carboxymethyl- 1,4,7- triazacyclononaneIBA 04/2024 - 03/2012
12	Designed Ankyrin Repeat ProteinsIBA 04/2024 - 01/2018
11	Epidermal Growth Factor (EGF)IBA 01/2021 - 05/2003
8	Peptides (Polypeptides)IBA 04/2024 - 01/2002
8	BombesinIBA 03/2023 - 01/2013
8	Epithelial Cell Adhesion MoleculeIBA 02/2023 - 02/2020
8	AntibodiesIBA 06/2020 - 08/2003
7	Pentetic Acid (DTPA)FDA LinkGeneric 12/2019 - 08/2003
7	Cys-ZHER2-342 affibodyIBA 01/2018 - 02/2007
6	LigandsIBA 03/2024 - 04/2006
6	Immunoconjugates (Immunoconjugate)IBA 01/2023 - 11/2006
6	AlbuminsIBA 02/2022 - 01/2018
6	ABY-025IBA 03/2020 - 04/2010
6	AndrogensIBA 07/2014 - 04/2011
5	Indium-111IBA 07/2021 - 04/2007
5	Tyrosine Kinase InhibitorsIBA 01/2021 - 11/2014
4	Hormones (Hormone)IBA 03/2023 - 04/2011
4	seribantumabIBA 02/2023 - 01/2018
3	Carbonic Anhydrase IXIBA 12/2019 - 11/2016
3	Cetuximab (Erbitux)FDA Link 01/2019 - 01/2011
3	Peptide Nucleic AcidsIBA 01/2018 - 01/2016
3	Biomarkers (Surrogate Marker)IBA 01/2018 - 07/2010
3	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 12/2017 - 03/2009
3	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 04/2016 - 01/2007
3	Cysteine (L-Cysteine)FDA Link 04/2015 - 03/2007
2	Amino Acids FDA Link 04/2024 - 06/2012
2	Glucose (Dextrose)FDA LinkGeneric 06/2022 - 02/2016
2	EpitopesIBA 11/2021 - 05/2012
2	Aligeron (AS 2)IBA 01/2021 - 06/2010
2	68Ga-ABY-025IBA 03/2020 - 01/2016
2	EnzymesIBA 01/2020 - 11/2016
2	G250 monoclonal antibodyIBA 12/2019 - 02/2015
2	CobaltIBA 11/2019 - 01/2017
2	Immunoglobulin FragmentsIBA 10/2019 - 02/2016
2	Technetium (Technetium 99m)IBA 01/2018 - 03/2006
2	pertuzumabIBA 01/2018 - 01/2007
2	Immunoglobulins (Immunoglobulin)IBA 01/2018 - 01/2016
2	CD44v6 antigenIBA 02/2016 - 01/2010
2	Oncogene Proteins (Oncogene Protein)IBA 10/2015 - 06/2006
2	IodineIBA 06/2014 - 03/2006
2	IndiumIBA 06/2014 - 11/2007
2	IsotopesIBA 07/2013 - 11/2004
2	RadiopharmaceuticalsIBA 03/2011 - 03/2007
2	DABIIBA 01/2010 - 11/2004
2	dodecaborateIBA 01/2010 - 11/2004
2	benzyl-DTPAIBA 09/2007 - 08/2003
2	N- (2- amino- 3- (para- isothiocyanatophenyl)propyl)cyclohexane- 1,2- diamine- N,N,N',N',N'- pentaacetic acidIBA 03/2007 - 11/2006
2	Benzoates (Benzoate)IBA 07/2006 - 11/2004
1	Immune Checkpoint ProteinsIBA 04/2024
1	Neprilysin (Neutral Endopeptidase)IBA 04/2024
1	glutamyl-glutamic acid (Glu-Glu)IBA 04/2024
1	glycyl-glycyl-glycine (triglycine)IBA 04/2024
1	PSMA-11IBA 12/2023
1	Bacterial ToxinsIBA 02/2023
1	ProdrugsIBA 01/2023
1	Peptide Hydrolases (Proteases)FDA Link 01/2023
1	OsteopontinIBA 05/2022
1	Alkaline PhosphataseIBA 05/2022
1	ExotoxinsIBA 05/2022

Therapy/Procedure

94	Therapeutics 04/2024 - 02/2002
7	Radioimmunotherapy 08/2015 - 10/2005
7	Gamma Cameras (Gamma Camera) 11/2014 - 04/2006
4	Radiotherapy 05/2024 - 01/2007
4	Precision Medicine 04/2024 - 10/2015
3	Castration 05/2024 - 05/2012
3	Investigational Therapies (Experimental Therapy) 01/2023 - 01/2007
2	Immunotherapy 01/2018 - 01/2014
2	Intravenous Injections 05/2014 - 05/2012
1	Neoadjuvant Therapy 01/2023
1	Cyclotrons 11/2021